You should store Zepbound single-dose pens or vials in the refrigerator at 36°F to 46°F (2°C to 8°C). But if needed, you can store them unrefrigerated for up to 21 days. During that time, the drug should remain at a room temperature that doesn’t exceed 86°F (30°C).
No, you should not refrigerate Zepbound again after taking it out of the fridge. Once you store Zepbound at room temperature, it’s important that you do not return it to the refrigerator. Instead, dispose of the medication.
You can check the:
- Drug Enforcement Administration (DEA)’s site for drug take-back locations available year-round in the United States
FDA’s drug disposal site to learn about the safe disposal of medications
Freezing Zepbound will ruin the medication, and you will not be able to use it again.
If Zepbound freezes, even partially, you need to dispose of the medication immediately. The same goes for when Zepbound has been exposed to other extreme temperatures or direct sunlight. For example, if you have left the pen inside a hot car or if you put Zepbound in a checked bag traveling in a plane’s cargo compartment.
Zepbound single-dose pens or vials need to be stored in the refrigerator or at room temperature for up to 21 days.
The storage information that applies to Zepbound also applies to storing compounded tirzepatide. The Food and Drug Administration (FDA) has not approved compounded drugs, though, and these drugs don’t come with a package insert that provides storage and safety tips.
It’s important to ask a doctor or pharmacist how to safely store a compounded drug.
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